The study set out to determine factors influencing non-compliance with clinical rehabilitation services in a rural African setting. This was a cross-sectional study, which was exploratory in nature. Data was collected from the rehabilitation defaulters in a rural setting in Zambia. Data was collected using a semi-structured questionnaire and summarized using descriptive statistics. The chi-square test was used to test associations and the confidence interval was set at 95%. A total of 160 respondents participated in the study. The majority of the respondents (n=63) 39% were unaware of rehabilitation services. Non-compliance was highly associated with unawareness of rehabilitation services (P<0.01). Distance from home was equally associated with non-compliance (p< 0.003). Awareness of health services provided is a very important factor contributing to compliance. Efforts to increase the compliance with rehabilitation services need to include community sensitization of rehabilitation services and improve community and family participation.