Resume. Spread of HIV infection among patients with opium addiction is a complex medical and social problem in which social as well as medical and biological aspects are of great significance. Purpose: to study the indicators of quality of life in HIV-infected patients who use PAS. 280 HIV-infected patients who use PAS and 120 HIV-infected patients who are not suffering from PAS dependence, aged 19-70 years have been examined. Experimental psychological, socio-demographic and statistical methods were used. The data of marital status analysis showed that in the main group 51,4% of patients had a complete family and 23,9% had no family. 17,5% of patients got divorced, the number of patients repeatedly married made 5,3%, in 1,9% of cases one of the spouses died. In the control group the number of married was 67,5%, divorced 5,9%, unmarried 17,5%, in the remarriage 7,5%, cases with death of one of the spouses 1,6%. These findings suggest that HIV-infected patients who use PAS compared with HIV-infected patients who do not use PAS are more vulnerable and unfavourable group from the standpoint of social interaction and adaptation.