Aim: The objective of this study was to study the prescribing pattern of antiepileptic medications in patients with epilepsy in a tertiary care hospital. Material & Methods: It was an observational study, conducted at Department of Pharmacology, Department of Pharmacology, ICARE Institute of Medical and Research & Dr.Bidhan Chandra Roy Hospital, Haldia, West Bengal, India from December 2013 to November 2014 Results: CNS related effects were seen in 14 patients followed by gastrointestinal disturbance in 8 patients. Out of 69 patients who were on monotherapy, most commonly prescribed AED was phenobarbitone (31) followed by phenytoin (18), levetiracetam (11), and carbamazepine (7), lorazepam (1) and ethosuximide (1). Conclusion: Majority of the patients were males with age group 20-40 years and most commonly used drugs were conventional AEDs as monotherapy with phenobarbitone, phenytoin and levetiracetam.