Background: The relevance of endometrioid ovarian cysts is due to their significant prevalence, progressive course with frequent recurrences and pain syndrome, development of adhesive process, infertility, deterioration of patients' quality of life, which encourages the search for new ways of correction in patients of this cohort.

The aim of the study was to investigate the effectiveness of using a combined preparation containing streptokinase and streptodornase as booster therapy for the prevention and reduction of the frequency of complications in the postoperative period in women with endometrioid ovarian cysts.

Methods: 39 women with ovarian endometriomas who underwent laparoscopic cystectomy were examined; they were divided into 2 groups: comparison group – 18 patients who received standard therapy in the postoperative period and study group – 21 patients who received standard treatment after surgery and additionally a combined preparation containing streptokinase and streptodornase rectally for 18 days; the control group included 105 conditionally healthy women.

The levels of SDH in blood serum, functioning of the LPO-AOD system, state of endogenous intoxication, phagocytic activity of neutrophils and monocytes, concentration of pro- and anti-inflammatory cytokines were determined; anxiety level was studied using the hospital HADS anxiety scale, depression – using the HADS depression scale, quality of life – using the CQLS questionnaire.

Results: It was established that the clinical picture in patients with endometrioid ovarian cysts is characterized by the presence of pain syndrome, sleep disturbance, weakness, fatigue, dyspareunia, deterioration of mental health and quality of life. Decreased activity of SDH, activation of LPO, increase in endotoxemia, decrease in phagocytic activity of neutrophils and monocytes, increase in cytokine levels with predominance of pro-inflammatory ones were revealed. The obtained results indicate that the use of a combined preparation with streptokinase and streptodornase in patients after endometrioma removal has significant advantages not only in the management of the postoperative period, but also in the prevention of mental health disorders, improvement of patients' quality of life, unlike standard treatment.