Bone is a dynamic tissue that is being remodels constantly throughout life. It is composed primarily of the inorganic materials (Ca and Phosphate) and organic matrix (type-1- collagen). Bone formation is orderly process in which inorganic mineral is deposited in relation to organic matrix. During the bone resorption first calcium and phosphorus are released in to the extra cellular fluids and organic matrix is then desorbed. The concentrations of Ca, Phosphate and Mg in plasma are dependent on the net effect of bone mineral deposition and resorption, then intestinal absorption and renal excretion. Osteoporosis is the term used for diseases that cause a reduction in the mass of bone per unit volume and is one of the dreaded afflictions of ageing. There is a close relationship between estrogen deprivation and its development. In the present study, we investigate the effect of age and body weight on blood indicators of bone health namely, Ca, Mg and P. Bone mineral marker ALP was used which have more advantages and predicting the postmenopausal bone loss. The subjects were classified in to three groups namely controls, premenopausal and postmenopausal. In our study blood levels of both Ca as well as Mg were found to be lowered in postmenopausal women. Mg and Fe are the major minerals that doctors find deficient in people who are overweight. Blood level of P is also declines in our study. So, that Ca: P ratios are maintained.