In our country Post exposure prophylaxis (PEP) is an ignored thing even in health care set ups. PEP usually reminds us about a dog bite but in clinical set ups due to needle stick injuries ( NSI) many viruses can cause life threatening diseases like Hep B Hep C and HIV/AIDS about which our HCW(Health care workers) pose apathy and ignorance So we need to apprise and equip with the correct and adequate scientific knowledge and information about the transmission of these viruses in different clinical scenario and how to safe guard against them There should be proper policy and protocol for management of such occupational exposures.