The term 'enteric fever' is a collective term that refers to severe typhoid and paratyphoid. Typhoid fever, also known simply as typhoid, is a bacterial infection due to Salmonella typhi that causes symptoms which may vary from mild to severe and usually begin six to thirty days after exposure. The objective of the present study is to evaluate the clinical profile and pattern of various drugs used in the treatment of typhoid fever. The patients admitted to IPD of SRMS Institute of Medical Sciences, Bareilly were considered in the study. The approval of the Ethical Committee is taken from the Hospital. The written consent also obtained from the patients. The total 50 patients were included in the study. The mode of presentation, clinical course, treatment history, laboratory investigations reports, antibiotic administered response to therapy and the complications were recorded. Maximum resistance for chloramphenicol, amoxicillin, and ampicillin was seen as compared to ceftriaxone and ciprofloxacin. Also Maximum sensitivity is also seen in Cefriaxone. The maximum patients show the Fever and abdominal pain as the main symptoms. Other symptoms includes the chills, headache, constipations, diarrhoea, vomatting, myalgia, cough etc.