The present study was planned to know the outcome of oral aspirin in dropping the incidence of post-operative myalgia triggered by administration of suxamethonium and to relate it with precurarization (with pancuronium) and with a control. GROUP A: Patients in this group were precurarised by giving injection pancuronium 0.01 mg/kg body weight intravenously three minutes before commencement of induction of anesthesia. GROUP B: Patients in this group were given soluble aspirin (tablet Disprin) 600 mg orally one hour before induction of the anesthesia. GROUP C: No pretreatment was given In group A there are 4 cases are of mild pain and 1 cases of moderate pain. In group B there are 5 cases are of mild pain and 2 moderate pain. In group C there are 8 cases are of mild pain and 6 moderate pain. In Group A patients without aspirin 15 cases showed no fasciculation and 5 cases showed mild fasciculation. In group B administered with the aspirin 2 cases of no fasciculation observed, 12 cases are of mild fasciculation, 4 cases are of moderate fasciculation and 2 cases are of severe fasciculation. Preoperative aspirin 600mg orally 1 hr before operation effectively reduces Suxamethonium induced pain and avoid complications associated with pretreatment with non-depolarising agents.