Background: The current work was done to detect the knowledge and the behavioral practice about malaria and among Hail populations, Saudi Arabia. Material & Methods: A cross-sectional survey was done using structured questionnaire that was distributed among 1300 participants selected randomly from Hail region. Results: The results of the present study revealed that although most of the participants (67.0%) reported they were aware about malaria, however, their depth of knowledge was poor as regards the causative agent (7%), prophylaxis (5.5%) and treatment of malaria (25%). Unexpectedly, 68.0% of the respondents thought wrongly that malaria is treated by herbal preparation. Approximately 75.4 % of the participants in the present study thought that it was not a treatable disease and 82% of them believed that malaria is preventable. As expected, the main source of information was the internet and social media (78%). Although majority of the respondents associated thecause of malaria with mosquito bite, 52.2%, 43.1 %, 33.6 %, 44.7%, 58.6% of respondents believed wrongly that flies bites, Consumption of raw or inadequately cooked meat,sneezing or coughing, Consumption of unwashed vegetables and fruits, and physical contact can transmit malaria. respectively. In the current work, unfortunately knowledge about clinical manifestation was very deficient as demonstrated that 26.3% of contributors only knew that malaria cause regular fever whereas, 42.3%, 33.46% and 28.0% knew that malaria cause headache, coldness and shivering respectively. Surprisingly 28.2 % of respondents thought wrongly that malaria can cause eczema. Unfortunately, only 39.6% of participants sought treatment for malaria from hospitals or health facilities, 19% from pharmacists and 20% from relatives and friends’ advices. 57.1 % however sought traditional treatment. As regards personal prophylactic measures practiced by participants in the present study, 50.1% of people used to spray the anti-mosquito sprays and unfortunately,only 11% of the current study participants reported that they have mosquito nets in their houses. In the present work, only 9.46 % of the participants used to rub with skin repellant. Conclusion: In conclusion, the current study proved that Hail population have low level of knowledge as well as they are lacking the necessary preventive behavior to malaria infection. However, most of the preventive behaviors that are applied could be explained by the economic, and cultural habits in the region. Furthermore, the physicians should be at the first line to educate people about mode of transmission. Moreover, the current study could put a baseline information regarding knowledge and behavioral practice related to malaria disease.