The practice of herbal medicine dates back to the very earliest period of known human history - There is evidence of herbs used in the treatment of diseases and for revitalizing body system in almost all ancient civilization. Ayurveda, the Science of Life, has provided a rational basis for treatment of various ailments. Pain, inflammation and fever are common complications in human beings – In this paper, the autors have analysed how antipyretic activity of “Anjanavaerathichooranam” in yeast induced pyrexia are used in curing the disease.