Background: Obesity is a major growing global health problem of recent times. It is a leading preventable cause of death worldwide, with increasing rates in adults and children. Obesity, diabetes and hyperlipidaemia have been traditionally considered as diseases of affluence. The accumulation of central fat and presence of insulin resistance have associated with the dyslipidaemia seen in metabolic syndrome Objective: To determine the correlation between insulin resistance (by HOMA-IR) and lipid profile among obese adults. Material and Methods: A total of 100 obese individuals (BMI>25 Kg/m², WHR >0.9 in men, >0.8 in women) between the age group 18-60 years were included in this study. Fasting venous blood samples were collected and analyzed in auto analyzer for fasting blood glucose (FBG), Total cholesterol (TC), triglycerides, HDLc by enzymatic method, LDLc by Friedewald formula and insulin by immunofluoroscent method. Insulin resistance was calculated by a homeostasis model assessment (HOMA-IR) index (Fasting plasma glucose [mmol/L]X fasting plasma Insulin[uU/ml] /22.5) Results: There was significant correlation between BMI and Insulin Resistance. Lipid profile were positively correlated with HOMA-IR whereas HDL showed negative correlation and all associations were statistically significant (p<0.001). Conclusion: Our study reveals that there is a strong relationship between insulin resistance and lipid profile in obese adults