India being a developing country has high incidence of burns which is about seven millions. Topical anti-microbial agent is an effective way to decrease to bacteria load in burns patients traditionally silver sulfadiazine is used as topical agents but now newer nano silver colloid preparations are more efficient in this regards.

Materials and Methods: 40 patients divided two groups (each groups consisting 20 patients) one group used silver sulfadiazine and other groups used nano silver colloid agent tropically as antimicrobial agent. Results of the both the groups are compared using statistical analysis

Results: Nano silver colloid are more efficient in treatment of pediatric Second degree Burn associated with less pain.

Conclusion: Nanosilver colloid preparations are an effective alternative in treatment of 2nd degree burns in pediatric patients.