There remains a gap in the conclusiveness of the importance of the glycemic index hypothesis.This study investigated the overall postprandial glycemic effects of four common Ghanaian meals in non-diabetic adult subjects.After an overnight fast, the test meals (Ampesi, Fufu, Banku and Ga Kenkey) served as mixed meals were consumed by the participants on separate days. Blood glucose levels were observed at baseline and 30-minutes intervals for three (3) hours. Postprandial outcomes were assessed as the Total postprandial glycemia area under-the-curve, Peak percentage postprandial glycemia and percentage postprandial glycemic retention. The results of the study showed that with little variations, there were no significant differences in the overall postprandial glycemic responses of the meals, despite previously quoted differences in glycemic indexes of the foods. The relative differences in their postprandial glycemic patterns may rather suggest implications in individuals on insulin therapy in terms of dosage and timing.