Acute encephalitis syndrome (AES) is a serious public health problem in India. It is characterized as acute-onset of fever and a change in mental status (mental confusion, disorientation, delirium, or coma) and/or new-onset of seizures in a person of any age at any time of the year. The disease most commonly affects children and young adults and can lead to considerable morbidity and mortality. Hence based on above findings the present study was planned for Evaluation of Paediatric Cases Suffered from Acute encephalitis syndrome in to DMCH. The present study was planned in Department of Pediatrics, Darbhanga Medical College and Hospital Darbhanga, Bihar. Total 20 cases of Acute Encephalopathy Syndrome were enrolled in the present study. After admission, detailed history was taken and management of fever, raised ICT and seizure were carried out simultaneously. Clinical examinations were done. Urgent supportive management, and blood samples were sent for different baseline biochemical tests. Blood and urine samples were sent for culture and sensitivity in all cases by maintaining proper aseptic technique. Neuroimaging and CSF analysis were performed in all cases of fever with altered sensorium. The data generated from the present study concludes that AES is a major illness affecting children of Bihar as well as other parts of country with significant morbidity and mortality. Its control is very important from public health aspect as it has significant impact on resources of state, nation and public exchequer. Most importantly, the chance of lifelong sequalae leaves scarring on the face of survivor, their family and society.