Birth weight is considered the major determinant of neonatal deaths in technologically developed countries. There is a relationship between low birth weight and infant morbidity and mortality. The lower the birth weight, the higher the mortality. The relatively high incidents in the US are considered as a key factor in its higher neonatal mortality rates when compared with other countries. Hence based on above findings the present study was planned for Clinical Outcomes of the NICU Graduates Weighing Less than 2500 Grams in Bihar region. The Present study was planned in Department of Pediatrics, Darbhanga Medical College & Hospital, Laheriasarai, Bihar. The 25 cases of the NICU graduate weighing less than 2500 gms were enrolled in the present study. The various antenatal and perinatal risk factors had not shown significant correlation with developmental outcome at one year of age. This could be due to the small sample size and short term follow up of low birth weight babies. Perhaps a larger sample size and long term follow up will yield more conclusive data.