Blood culture remains the gold standard and goes hand in hand with the clinical symptoms in arriving at the diagnosis. But it is time consuming, requires well equipped laboratory and trained personnel. And not all the cases of neonatal sepsis show culture positivity. In case of neonatal sepsis the culture positivity is only moderate. So development of novel early diagnostic markers of sepsis like pro-calcitonin, interleukin-, C-reactive protein etc., help in early assessment of infection, reducing the mortality and sequelae. They are now used in conjunction with blood culture in diagnosing sepsis in neonates. All these variables help in very early diagnosis and in prompt institution of anti-biotic therapy only when indicated thus avoiding their indiscriminate usage. This helps the neonate to bypass the unnecessary adverse effects of anti-biotic administration, makes the treatment cost effective and prevents the emergence of multi- drug resistant strains. Hence based on above findings the present study was planned for Clinical Assessment of Association of C-Reactive Protein and Blood Culture in Neonatal Sepsis Cases. The present study was planned in Department of Pediatrics, Nalanda Medical College, Patna, Bihar, India. The present study was conducted from March 2015 to Oct 2015. In the present study 50 cases of the suspected neonatal septicemia were enrolled and evaluated with different parameters. The data generated from the present study concluded that biomarkers like CRP may serve as an important tool in reducing the mortality and morbidity among neonates diagnosed from sepsis. Also biomarkers like CRP may serve as an important tool in reducing the mortality and morbidity among neonates.