In developing countries, infectious diseases contribute considerably to morbidity and mortality. Sometimes concurrent infections with multiple infectious agents may occur, which make the correct diagnosis and management a challenging task. Hence the present study was planned for evaluation of case of co-infection of typhoid fever with dengue fever. Hence based on above finsgins the present study was planned for study of Correlation of Dengue Fever and Enteric Fever in Childrens. The present study was planned in Department of Pediatrics, Darbhanga Medical College and Hospital Darbhanga, Bihar. Total 25 cases of the Dengue fever were enrolled in the present study. Dengue viral infection was confirmed by observing the platelet count decreased (less than 150000 platelets per microliter of blood) from normal level. Clinical characteristics of Dengue fever patients showed Fever, headache, muscle aches and thrombocytopenia. Apart from the dengue symptoms, patients Co-infected with typhoid fever showed coated tongue, fatigue, Sweating, Dry cough, Loss of appetite and weight loss and abdominal pain. The patient serum was tested for Dengue virus NS1 and/or IgM samples. The Widal test used for the antibody titer and titer value of >1:80 considered as clinically significant. The data generated from the present study concludes that the high prevalence rate of Dengue fever may leads to co-infections with typhoid are common and it should be properly diagnosed and timely medication should be provided to reduce complications and also to avoid mortality.