We report an observation of polyparasitism with Schistosoma intercalatum associated with Ascaris and Trichocephalus in a young woman aged 22 years old, nurse, native of Equatorial Guinea, resident in an urban environment with a notion of swimming, who had been presenting a dysenteric syndrome for two days. Clinical examination revealed pain in the right iliac fossa and pelvis. The hemogram showed leukopenia and lymphopenia with normal eosinophilia. The three-day parasitological examination of the stool revealed the existence of eggs of Schistosoma intercalatum, Ascaris lumbricoides, and Trichuris trichiura. Bilharziasis serology was positive with a titre of 1/160 and rectoscopy was without abnormalities. The patient was put on treatment with a good clinical and biological evolution.