Patient with hypertension and heart failure disease are at increased risk of severe corona virus disease 2019 caused by the SARS-CoV-2 virus, while also causing acute myocardial injury and chronic damage to the cardiovascular system. Angiotensin converting enzyme – 2 is a membrane bound aminopeptidase which is play an important role in heart function, development of blood pressure and immune systems and also has been identified as functional receptor for SARS CoV-2. The debate is for clinical use of angiotensin converting enzyme inhibitors and angiotensin receptor blockers in CVD and COVID-19 patients during the outbreak of novel corona virus.