Aim: To assess the improvement in lipid profile (TC, TG, LDL and HDL) in patients of type 2 diabetes mellitus who were previously on metformin monotherapy with uncontrolled diabetes. Material and Method: This prospective analytical study was carried out in the Department of Pharmacology at Anugrah Narayan Magadh Medical College and Hospital, Gaya, Bihar from October 2019 to March 2020. A total of 100 patients were enrolled who were on metformin monotherapy and with uncontrolled diabetes. Patients were given metformin 500 mg twice a day and saxagliptin 2.5 mg once a day. Patients were followed up at First, Third and Sixth month and lipid profile (TC, TG, LDL and HDL) estimation was done during the follow up period. Results: Amongst the 100 patients’ studies for diabetes 65 of the patients were male and 35 were female. Most commonly affected age group was 50 to 60 years of age followed by 40-50 years of age. The mean change in value from baseline at 24 weeks was TC=13.60± 17.71, TG = 10.63± 19.79, LDL = 11.59± 17.29, HDL = 2.24± 5.77. A highly significant difference has been seen at 0 v/s 1, 0 v/s 3 and 0 v/s 6 months in TC, TG, LDL and HDL values. Conclusion: Saxagliptin has shown an improvement in lipid profile (TC, TG, LDL, HDL) during 6 months of treatment in patients of type 2 DM.