Background: Menstruation is an important event in the life of a girl and is often associated with menstrual problems such as irregular menstruation, excessive bleeding, dysmenorrheal, spotting etc. It is expected that the girls have proper knowledge about the reproductive issues and their sanitation practices, so that they can protect themselves from the unwanted medical threat. The objective of the study is to assess practices on menstruation hygiene and the awareness about some reproductive issues and. Data and Methods: The data for this study is taken from a sample survey from girl’s hostel located in the Banaras Hindu University, Varanasi. A total of 308 under graduate and postgraduate students provided information on the menstrual hygiene, sanitation practices and about some reproductive issues. Consent is taken from the girls prior to conduct the study using structured questionnaire. Results: Sixty percent girls mentioned that dysmenorrhea is the major menstrual problem. The practices of menstrual hygiene i.e. using sanitary napkins among girls were found to be 93.5 percent. 81 percent reported normal bleeding rest are facing heavy or spotting. Conclusion: Dysmenorrhea, irregular period and heavy bleeding is the most common menstrual problem among girls. Some of the girls have little awareness about the reproductive issues thus there is an imperative need of some intervention program related to the issues discussed here for the improvement of the girl’s knowledge to avoid menstruation and reproductive issues related medical burden.