Objective: To assess the prevalence of dépression among chronic kidney disease patients undergoing hemodialysis. Materials and Method: A hospital based Cross Sectional study was conducted on 106 patients in Hemodialysis Unit of Department of Nephrology, Kamineni Academy of medical sciences, and Hyderabad from the year January 2019- December 2020. Collected data were analyzed by using SPSS Ver. 25. Results: A total of 106 patients were screened out of which 67 were males and 39 were female. The mean age of patients was 52.73 + 11.22 years. Out of 106 patients 65 had depressive symptoms. The depressive disorders was higher in the age group more than 60 years. In the current study among sociodemographic factors including gender, marital status, education, type of family and income were taken into consideration. The factors which was not significantly associated with depression were gender, type of family and family income. Conclusion: In our study we observed that the prevalence of depression was more common in CKD patients undergoing hemodialysis. Patients’ Body Mass Index & residence were found to be significant relationship with CKD patients. Therefore, an early diagnosis of depression could be helpful in improving the quality of life of CKD patients.