Methods: We conducted a prospective observational study based on historical data of quadrivalent vaccination in patients presenting to the Emergency Department (ED) with influenza like illness (ILI) over a period of 5 months (April 2020 to August 2020). The purpose of this study was to determine whether there is any correlation for Covid-19 among vaccinated patients compared to unvaccinated patients.

Results: During the study period, a total of 1237 patients with a mean age of 51.6 years presented to the ED with Influenza like illness. Majority of the patients were not vaccinated with any flu vaccine (93.2%). Among the study population 144(11.6%) patients were tested to be COVID 19 positive. Only 3(3.6%) patients who were vaccinated turned positive compared to non-vaccinated group [3.6% vs 12.2%; OR: 0.266: 95% CI- 0.008- 0.852; p=0.026].

Conclusion:This vaccination strategy will help fight against COVID-19 and other flu virus until we come up with a time tested specific vaccine for COVID-19. We recommend that administering quadrivalent vaccine to vulnerable population, frontline health care workers and pregnant women will decrease the incidence of COVID-19 during this pandemic.