Background: It is estimated that about 60% infectious waste less often disposed improperly, which makes a path for the transmission of infection such as HIV, HBV etc. to health care providers unknowingly. Material and methods: An evaluative research approach, pre experimental one group pre-test and post-test design was usedfor the study. 30 student nurses were selected by convenient sampling technique from Athena College of nursing, Mangalore. Significant difference between pre-test and post-test knowledge scores were analyzed by using paired t-test Results: The results of the study shows that the pre-test knowledge score regarding biomedical waste management with the mean pre-test of (13.97).whereas post-test score with a mean of (17.67) .The mean difference between the pre-testand post-test knowledge score was found to be significant (t29=2.05, P<0.05)level of significance. Conclusion: Study can be concluded that planned teaching programme is an effective strategy for providing information regarding biomedical waste management and to improve the knowledge of 2nd year Bsc nursing students.