Congenital Cytomegalovirus (CMV) infection is the most common congenital infection worldwide. It affects every 150-200 live births in developing countries. Yet there is low public and healthcare provider awareness about this preventable disease. It mainly affects the central nervous system and causes microcephaly, mental retardation. Progressive and permanent SNHL, chorioretinitis and developmental delay. Here we present a case of a 15 months old girl with repeated convulsion, hearing loss, visual impairment, motor delay, and mental retardation organomegaly and growth failure. CMV is seen in approximate 1% of all newborns. From 10%-15% of congenitally infected newborn cases are symptomatic at birth. Among them 90% having various types of sequels like hearing loss (most common) to severe mental retardation, motor delay chorioretinitis (inflammation of choroid and retina), behavioural disorder and seizure.