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VOL. 8, ISSUE 1 (2022)
Endothelial dysfunction as an independent risk factor for cardiovascular disease in patients with metabolic syndrome: A prospective study in a tertiary hospital from central India
Authors
Premshanker Singh, Ritu Karoli, Prafull Kumar Singh
Abstract
Background: The objective was to evaluate endothelial dysfunction as an independent risk factor for cardiovascular disease in patients with metabolic syndrome. Methods: This prospective, cross-sectional, hospital based observational study included 90 patients with metabolic syndrome and 40 age and sex matched controls who attended hypertension clinic, diabetes clinic, general medicine OPD and patients admitted in wards, department of medicine, Dr RML Institute of Medical Sciences, Lucknow India. All patients who fulfilled inclusion criteria were subjected to the color Doppler of the brachial artery in the department of radio- diagnosis of the same institute. Results: 90 patients with metabolic syndrome included in the study, 44 patients (48.9%) were males and 46 patients (51.1%) were females. Twenty males (45.5%) had a waist circumference of >90 cm whereas 40 females (87%) had waist circumference of >80 cm. 18 males (40.9%) had abnormal waist hip ratio whereas 44 females (95.7%) had abnormal waist hip ratio. 86 patients (95.6%) had a SBP >130 mm of Hg whereas 78 patients (86.7%) had a DBP >85 mm of Hg. 48 patients (53.3%) had impaired fasting blood sugar i.e. >100 mg/dl,50 patients (55.6%) had a TGL level >150 mg/dl, and 18 males (40.0%) had HDL < 40 mg/dl whereas 36 females (78.3%) had HDL value < 50 mg/dl respectively. The mean brachial artery baseline diameter were 3.51 ± 0.40 mm in males and 3.26  0.30 mm in females respectively, FMD percentage was 14.92  3.56 in females and 14.53  4.02 in males, and GTN mediated dilatation were 27.67  9.83% in females and 27.62  6.86 % in males respectively. Conclusion: Estimation of Endothelial Dysfunction in patients at risk of developing full blown Metabolic Syndrome may predict the cardiovascular morbidity and mortality independently in these individuals even before fulfilling the 3/5 criteria of NCEP/ATP III Guidelines for the diagnosis of metabolic syndrome.
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Pages:26-31
How to cite this article:
Premshanker Singh, Ritu Karoli, Prafull Kumar Singh "Endothelial dysfunction as an independent risk factor for cardiovascular disease in patients with metabolic syndrome: A prospective study in a tertiary hospital from central India ". International Journal of Medical and Health Research, Vol 8, Issue 1, 2022, Pages 26-31
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