Vitamin D-dependent type two rickets (VDDRII) is a rare autosomal recessive disorder caused by a mutation in the vitamin D receptor gene, leading to end-organ resistance to 1,25(OH)2 vitamin D3. A patient with this condition presents with refractory rickets and growth retardation during the first year of life. It is frequently associated with alopecia totalis. Due to target organ resistance, its response to vitamin D is poor. The recommended treatment is supraphysiological doses of 1, 25(OH)2 vitamin D3 and a high dose of oral or intravenous calcium. The response of alopecia to treatment is generally poor. A case of a 15-month-old female child with VDDRII whose rickets partially responded to 1, 25(OH)2 vitamin D3 but showed poor response of alopecia to the treatment is presented.