ARCHIVES
VOL. 8, ISSUE 1 (2022)
Clinico-pathological profile and outcomes of C3 glomerulopathy in north India: A single centre study
Authors
Shivendra Singh, Prem Shankar Patel, Archana, Harish Saini, Khushboo Rani
Abstract
Introduction: C3 glomerulopathy is a rare variety of complement mediated glomerulonephritis includes C3GN and DDD. Its histological hallmark is dominant C3 deposition in glomerulus. The clinical presentation and outcome of C3G is widely variable. Material and Methods: 22 cases with only C3 deposits on kidney biopsy were enrolled in the study during January 2018 to January 2020. They were classified into C3GN and DDD. All received supportive and immunosuppressive therapy and were followed up for 6 months. Outcomes were measured as remission rate and progression to CKD or ESRD. Results: C3G constituted 22 cases (2.8%) of total renal biopsy. 19 cases had C3GN and 3 had DDD. Mean age was 25.5 years in C3GN and 27.7 years in DDD. RPGN was commonest (47%) presentation in C3GN followed by NS (26%) and AUA (21%). Presentations of DDD were AUA, RPGN, and CKD one in each patient. Mean proteinuria was 3.6 gm/ 24 hours in both groups. Mean serum creatinine was 3.64 mg/dl in C3GN and 4.2 mg/dl in DDD. MPGN was predominant lesion in both groups. Crescents found in both C3GN (47%) and DDD (33.3%). 57.8% patients with C3GN had complete or partial remission; while only one DDD had complete remission. Rest of the C3GN and DDD patients progressed to either CKD or ESRD. Conclusion: C3G noted in 2.8% of biopsies. RPGN was commonest clinical presentation, and MPGN was commonest histological lesion in C3G. Overall, C3GN had better treatment response than DDD. Despite treatment 8 out of 19 C3GN and 2 out of 3 DDD cases progressed to either CKD or ESRD.
Download
Pages:49-53
How to cite this article:
Shivendra Singh, Prem Shankar Patel, Archana, Harish Saini, Khushboo Rani "Clinico-pathological profile and outcomes of C3 glomerulopathy in north India: A single centre study ". International Journal of Medical and Health Research, Vol 8, Issue 1, 2022, Pages 49-53
Download Author Certificate
Please enter the email address corresponding to this article submission to download your certificate.