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VOL. 8, ISSUE 1 (2022)
Cardiorespiratory depression in infant following unintentional ingestion of brimonidine tartrate, and use of naloxone as an antidote: Case report
Authors
Abdulmajeed Mohammed Alrashoud, Abdullah Mohammed Kamel, Mohammed Yahya Tairi, Imran Ahmad Gattoo, Seham Abdu Alhajoori
Abstract
Context: Brimonidine, a topical ophthalmic medication used to treat open-angle glaucoma or ocular hypertension. Brimonidine misused in children can cause serious side effects. Oral ingestion of brimonidine eye drops can lead to cardiorespiratory and central nervous system depression. Objective: We report an 80-days-old boy who developed cardiorespiratory depression due to accidental ingestion of brimonidine, and he responded to antidote Naloxone. Patient: The patient is an 80-days-old boy who came to the PED as a case of drug ingestion (brimonidine tartrate) that was used as eye drops by his older brother for his open-angle glaucoma. His four-year-old sister accidentally put the drops in his mouth. After 1 hour, the mother noticed that the baby started to cry, refused to feed, and became irritable. On arrival to our emergency at evening time, the patient was agitated, irritable, unable to open his eyes, drooling, and started to develop bradycardia and bradypnea. Conclusions and Outcome: Oral ingestion of brimonidine eye drops can lead to cardiorespiratory and central nervous system depression. Naloxone can be a beneficial modality of treatment to reverse these symptoms in such patients. Early presentation and prompt use of antidote in such cases can even eliminate the need for mechanical ventilation.
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Pages:61-62
How to cite this article:
Abdulmajeed Mohammed Alrashoud, Abdullah Mohammed Kamel, Mohammed Yahya Tairi, Imran Ahmad Gattoo, Seham Abdu Alhajoori "Cardiorespiratory depression in infant following unintentional ingestion of brimonidine tartrate, and use of naloxone as an antidote: Case report ". International Journal of Medical and Health Research, Vol 8, Issue 1, 2022, Pages 61-62
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