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VOL. 8, ISSUE 1 (2022)
To study lipid profile in patients of rheumatoid arthritis and it’s correlation with inflammatory markers
Authors
Saurav Kumar Dubey, Shirobhi Sharma, Nishant Wadhera
Abstract
Aim: To evaluate lipid profile in patients of rheumatoid arthritis and it’s correlation with inflammatory markers. Material and Method: The present study was conducted in the department of Medicine at Chattrapati Shivaji Subharti Hospital among 50 diagnosed cases of rheumatoid arthritis. Extra articular manifestations of Rheumatoid arthritis (eg. ILD, secondary Sjogren’s, and the disease activity measured according to (DAS 28, no. of tender joints and no. of swollen joints scoring system) was also accounted for and was matched against other parameters. Serum uric acid levels, serum lipid levels and inflammatory markers levels (E.S.R, C.R.P R.A factor), was measured after overnight fasting by enzymatic methods using the chemical analyzer. Results: The mean±SD of the age of study population was found to be 46.98±12.37 years. The RA was inactive in 28 (56%) of the study population. A strong positive correlation could be established with the total cholesterol and ESR as well as CRP levels. Reduced levels of HDLC are significantly correlated with the ESR as well as CRP levels. A significant positive correlation could be established with the increased LDL and ESR as well as CRP levels. Conclusion: In summary, our study supports the observation that patients with rheumatoid arthritis have a more atherogenic lipid profile even in the preclinical phase of rheumatoid arthritis, which ultimately could explain the increased cardiovascular risk in patients with rheumatoid arthritis. Furthermore, we show that inflammation is associated with a (further) deterioration of the lipid profile.
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Pages:38-42
How to cite this article:
Saurav Kumar Dubey, Shirobhi Sharma, Nishant Wadhera "To study lipid profile in patients of rheumatoid arthritis and it’s correlation with inflammatory markers ". International Journal of Medical and Health Research, Vol 8, Issue 1, 2022, Pages 38-42
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