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VOL. 8, ISSUE 1 (2022)
Correlation of serum prolactin level to child pugh scoring system and meld score in liver cirrhosis
Authors
Vikash Singh, Sumit Kant Jha, Saurabh Singhal, Akanksha Singh
Abstract
Aim: To assess the relation between serum prolactin levels and the severity of the disease (assessed by the Child Pugh system and MELD Score) in patients with cirrhosis of the liver. Materials and Methods: The cross sectional study was carried out in Chattrapati Shivaji Subharti Hospital, Meerut in the Department of Medicine. 100 cases with cirrhosis of the liver and/or its complications, with their full informed consent were included in the study. The patients underwent a detailed history including past, treatment and personal history to identify possible etiologies and a thorough clinical examination to identify the evidence of cirrhosis of the liver and the presence of its complications including portal hypertension and ascites. The patients were scored based on the modified Child Pugh and MELD scoring system Results: It was found that serum prolactin>19 was reported among 97.78% of the subjects having Child Pugh Score of 10-15. Similarly MELD score of 20-29 and ≥30 was found among 95.24% and 100% of the subjects having serum prolactin>19 respectively. It was found that significant positive correlation was found between prolactin level and Child Pugh as well as MELD scores i.e. with increase in Child Pugh and MELD scores, serum prolactin level also increases. 12.5% and 75% of the subjects having serum prolactin levels between 20-35 and 35-60 ng/ml respectively, suffered from mortality. Conclusion: We concluded that serum prolactin levels can be used as a useful prognostic marker in patients with cirrhosis of the liver as well as an early indicator of its complications. Also prolactin level not only helps in assessing the severity of the disease, it also helps in predicting the mortality.
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Pages:70-75
How to cite this article:
Vikash Singh, Sumit Kant Jha, Saurabh Singhal, Akanksha Singh "Correlation of serum prolactin level to child pugh scoring system and meld score in liver cirrhosis ". International Journal of Medical and Health Research, Vol 8, Issue 1, 2022, Pages 70-75
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