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VOL. 8, ISSUE 1 (2022)
Serum prolactin levels in patients with seizure disorder
Authors
Sarthak Mittal, T R Sirohi
Abstract
Aim: To evaluate whether prolactin levels can be used as a biochemical marker for differentiating between epileptic and non- epileptic seizures, and to correlate the levels with post-ictal duration. Materials and Methods: This prospective observational study was conducted at the Chattarpati Shivaji Subharti Hospital, Meerut in the Department of Medicine among 50 cases with previously or newly diagnosed seizure disorders presenting to the hospital were selected on the basis of a detailed clinical history and EEG. The serum prolactin levels were measured, from a sample taken within 30 minutes of the event, in all these patients to look for any correlation with seizure disorder or non-epileptic seizures. In case of an admitted patient having a seizure the serum prolactin levels were measured from a sample drawn within 30minutes of the event, and then another sample drawn 24 hours post-event. Results: Out of total subjects, majority of subjects had generalized seizures (48%), followed by partial seizures (28%). The proportion of subjects having pseudo-seizures was 24%, The mean±SD of postictal prolactin of subjects having generalized type was 1780.31±624.49 (mIU/L) whereas for the subjects having partial seizures was 592.08±509.11 (mIU/L) and for the subjects having pseudo- seizures was 381.15±172.90 (mIU/L). The inter group comparison showed statistically significant difference in the mean postictal prolactin levels in patients of epileptic seizures and pseudo seizures (p<0.01). Conclusion: The levels of serum Electrolytes (sodium, magnesium, calcium) decrease in various types of seizures except PNES in which electrolytes (sodium, magnesium and calcium) showed no significant change while potassium remains nearly normal in all types of seizures. Prolactin estimation can be a useful biomarker to differentiate Epileptic seizures from PNES.
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Pages:76-81
How to cite this article:
Sarthak Mittal, T R Sirohi "Serum prolactin levels in patients with seizure disorder ". International Journal of Medical and Health Research, Vol 8, Issue 1, 2022, Pages 76-81
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