Despite the widespread use of selective serotonin reuptake inhibitors (SSRIs) in medical practice, they are associated with a number of adverse effects. severe gastrointestinal bleeding, especially if they are also taking non-steroidal anti-inflammatory drugs (NSAIDs) or certain other classes of drugs. These drugs can increase stomach acid secretion and inhibit the entry of serotonin into platelets. The report found worrisome interactions with NSAIDs such as ibuprofen and Naproxen, as well as anticoagulants - Warfarin or antiplatelet drugs - Aspirin and Clopidogrel. The real risk comes from the assumption that each of these drugs is relatively safe and benign, but they all carry a risk of bleeding, and this risk increases when these drugs are taken now. This entire article is to address bleeding often from the gastrointestinal tract associated with the concomitant use of SSRIs with anticoagulants and antiplatelets.